{"id":29572,"date":"2025-10-23T18:53:31","date_gmt":"2025-10-23T16:53:31","guid":{"rendered":"https:\/\/www.neolifesalud.com\/blog\/sin-categorizar\/la-fda-reconsidera-els-seus-advertiments-sobre-la-terapia-hormonal-a-la-menopausa-linici-duna-nova-era-per-a-la-salut-femenina\/"},"modified":"2025-10-23T18:53:31","modified_gmt":"2025-10-23T16:53:31","slug":"la-fda-reconsidera-els-seus-advertiments-sobre-la-terapia-hormonal-a-la-menopausa-linici-duna-nova-era-per-a-la-salut-femenina","status":"publish","type":"post","link":"https:\/\/www.neolifesalud.com\/ca\/blog\/equilibri-hormonal\/la-fda-reconsidera-els-seus-advertiments-sobre-la-terapia-hormonal-a-la-menopausa-linici-duna-nova-era-per-a-la-salut-femenina\/","title":{"rendered":"La FDA reconsidera els seus advertiments sobre la Ter\u00e0pia Hormonal a la Menopausa: l’inici d’una nova era per a la salut femenina?"},"content":{"rendered":"
\n

La combinaci\u00f3 d’estradiol bioid\u00e8ntic i progesterona micronitzada ha mostrat a la literatura cient\u00edfica nul\u00b7la associaci\u00f3 amb esdeveniments tromb\u00f2tics ni augment de c\u00e0ncer de mama.<\/strong><\/h1>\n

Els advertiments sobre TRH es remunten a l’any 2002 amb l’estudi WHI (Women’s Health Initiative), que va vincular la ter\u00e0pia combinada CEE+MPA (Estr\u00f2gens Conjugats Equins + Medroxiprogesterona) amb un augment en el risc de c\u00e0ncer de mama i esdeveniments cardiovasculars.<\/em><\/p>\n

Dr. Alfonso Gal\u00e1n – Equip M\u00e9dic Neolife<\/em><\/p>\n

\n

Dones amb s\u00edmptomes debilitants van ser allunyades d’un tractament efica\u00e7 per pors infundades, perdent qualitat de vida i protecci\u00f3 \u00f2ssia i vascular.<\/strong><\/p>\n

El juliol del 2025, la FDA (Administraci\u00f3 d’Aliments i Medicaments dels Estats Units) va convocar un panell d’experts per reavaluar l’evid\u00e8ncia sobre la Ter\u00e0pia de Reempla\u00e7ament Hormonal (TRH) en dones menop\u00e0usiques. Aquest fet marca un punt d’inflexi\u00f3 a la narrativa institucional que, durant d\u00e8cades, ha estat dominada per la por, els \u201cblack box warnings\u201d i una percepci\u00f3 err\u00f2nia de risc.<\/p>\n

<\/b><\/span><\/p>\n

Des de Neolife celebrem aquest pas com un acte de just\u00edcia cient\u00edfica i sanit\u00e0ria, per\u00f2 tamb\u00e9 com un recordatori de quant dany ha causat la desinformaci\u00f3 sobre la TRH. En aquest article analitzem en profunditat les conclusions del panell, els estudis clau discutits i, sobretot, que les formulacions que fem servir a Neolife (estradiol bioid\u00e8ntic i progesterona micronitzada) no han mostrat cap augment de risc cardiovascular ni de c\u00e0ncer.<\/b> <\/span><\/p>\n

\"TRHB<\/p>\n

Qu\u00e8 es va dir al panell de la FDA?<\/p>\n

    \n
  1. Eliminaci\u00f3 dels advertiments m\u00e9s severs (“black box warnings”) per a certes formes de TRH.<\/strong><\/li>\n
  2. Reconeixement de beneficis abans minimitzats: protecci\u00f3 cardiovascular, millora de la salut \u00f2ssia, reducci\u00f3 de sufocacions i millora de l’estat d’\u00e0nim, especialment en dones menors de 60 anys o els primers 10 anys postmenopausia.<\/li>\n
  3. Abs\u00e8ncia de distinci\u00f3 entre tipus de formulacions: una cr\u00edtica important va ser no diferenciar entre tractaments amb estr\u00f2gens conjugats equins (CEE) i medroxiprogesterona (MPA), davant d’opcions bioid\u00e8ntiques.<\/strong><\/li>\n<\/ol>\n

    El llegat del WHI i les seves conseq\u00fc\u00e8ncies<\/strong><\/p>\n

    Els advertiments sobre TRH es remunten a l’any 2002 amb l’estudi WHI (Women’s Health Initiative),<\/b> que va vincular la ter\u00e0pia combinada CEE+MPA amb un augment del risc de c\u00e0ncer de mama i esdeveniments cardiovasculars. Per\u00f2 els anys posteriors s’ha compr\u00e8s que: <\/span><\/p>\n

      \n
    • El risc observat no s’aplica a totes les formulacions ni a totes les dones.<\/li>\n
    • L’inici tard\u00e0 del tractament (edat mitjana a WHI: 63 anys) va distorsionar els resultats.<\/li>\n
    • No es van fer servir estr\u00f2gens bioid\u00e8ntics ni progesterona micronitzada.<\/li>\n<\/ul>\n

      Com a resultat, milions de dones van renunciar a una ter\u00e0pia beneficiosa, basant-se en pors que avui considerem infundades per a moltes pacients.<\/span><\/p>\n

      Evid\u00e8ncia actual: qu\u00e8 diu la ci\u00e8ncia sobre TRH bioid\u00e8ntica?<\/strong><\/p>\n

      Estudis com E3N (Fran\u00e7a) han demostrat que l’estradiol bioid\u00e8ntic combinat amb progesterona micronitzada<\/strong><\/span><\/p>\n

      Un metaan\u00e1lisis (Scarabin, 2018) confirma que la combinaci\u00f3n m\u00e1s segura es estradiol transd\u00e9rmico + progesterona micronizada<\/strong>,<\/b> sin aumento significativo de riesgo tromboemb\u00f3lico.<\/span><\/p>\n

      Difer\u00e8ncies entre formulacions<\/strong><\/p>\n

      \"TRHB<\/p>\n

      La posici\u00f3 de Neolife: evid\u00e8ncia, personalitzaci\u00f3 i seguretat<\/strong><\/p>\n

      A Neolife utilitzem TRH de forma personalitzada, amb:<\/span><\/p>\n

        \n
      • Estradiol bioid\u00e8ntic<\/li>\n
      • Progesterona micronizada<\/li>\n
      • Monitoritzaci\u00f3 anal\u00edtica i cl\u00ednica peri\u00f2dica<\/li>\n<\/ul>\n

        Aquesta combinaci\u00f3 ha mostrat a la literatura cient\u00edfica nul\u00b7la associaci\u00f3 amb esdeveniments tromb\u00f2tics ni augment de c\u00e0ncer de mama en \u00fas a curt o mitj\u00e0 termini.<\/span><\/p>\n

        \u00bfI ara qu\u00e9?<\/strong><\/p>\n

        Si la FDA est\u00e0 disposada a reconsiderar les advert\u00e8ncies severes sobre la base de l’evid\u00e8ncia actual, el pas l\u00f2gic seg\u00fcent \u00e9s retractar-se i disculpar-se <\/strong>pel dany ocasionat durant dues d\u00e8cades. Dones amb s\u00edmptomes debilitants van ser allunyades d’un tractament efica\u00e7 per pors infundades, perdent qualitat de vida i protecci\u00f3 \u00f2ssia i vascular. <\/span><\/p>\n

        La medicina ha de tenir el valor de rectificar. Avui sabem que la TRH ben indicada, amb formulacions bioid\u00e8ntiques i personalitzades, \u00e9s una eina poderosa, efica\u00e7 i segura per a moltes dones. <\/span><\/p>\n

        Conclusi\u00f3<\/strong><\/p>\n

        El panell de la FDA marca un canvi de rumb, per\u00f2 encara hi ha cam\u00ed per fer, molts metges i molts pacients per educar. A Neolife portem anys aplicant un enfocament basat en evid\u00e8ncia, allunyats del dogma i amb la seguretat com a prioritat. \u00c9s el moment de reescriure la narrativa de la TRH, amb ci\u00e8ncia, prud\u00e8ncia i respecte per la salut femenina.<\/p>\n

        <\/span><\/p>\n

        \n

        BIBLIOGRAFIA<\/p>\n

        (1) Scarabin, P. Y.<\/strong> (2018). Progestogens and venous thromboembolism in menopausal women: an updated oral versus transdermal estrogen meta-analysis.<\/em> Climacteric<\/strong>, 21(4), 341\u2013345.<\/p>\n

        (2) Fournier, A. et al.<\/strong> (2008). Use of different postmenopausal hormone therapies and risk of histology- and hormone receptor-defined invasive breast cancer.<\/em> Journal of Clinical Oncology<\/strong>, 26(8), 1260\u20131268.
        \n(E3N cohort, Francia)<\/em><\/p>\n

        (3) Manson, J. E. et al.<\/strong> (2013). Menopausal hormone therapy and health outcomes during the intervention and extended poststopping phases of the Women’s Health Initiative randomized trials.<\/em> JAMA<\/strong>, 310(13), 1353\u20131368.<\/p>\n

        (4) The NAMS 2022 Hormone Therapy Position Statement Advisory Panel<\/strong>. (2022). The 2022 Hormone Therapy Position Statement of The North American Menopause Society.<\/em> Menopause<\/strong>, 29(7), 767\u2013794. <\/p>\n

        (5) FDA Expert Panel on Menopause and Hormone Replacement Therapy<\/strong> (2025). U.S. Food & Drug Administration Public Meeting Archive: July 17, 2025.<\/em><\/p>\n

        \n","protected":false},"excerpt":{"rendered":"

        La combinaci\u00f3 d’estradiol bioid\u00e8ntic i progesterona micronitzada ha mostrat a la literatura cient\u00edfica nul\u00b7la associaci\u00f3 amb esdeveniments tromb\u00f2tics ni augment de c\u00e0ncer de mama. Els advertiments sobre TRH es remunten a l’any 2002 amb l’estudi WHI (Women’s Health Initiative), que va vincular la ter\u00e0pia combinada CEE+MPA (Estr\u00f2gens Conjugats Equins + Medroxiprogesterona) amb un augment en […]<\/p>\n","protected":false},"author":7,"featured_media":29540,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[5412],"tags":[5422,5414,5420,5425,5417,5418,5168,5423,5419,5415,5413,5416,5421,5424],"class_list":["post-29572","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-equilibri-hormonal","tag-bioidentic","tag-cancer-de-mama-ca","tag-estradiol-ca","tag-estudi-whi","tag-ictus-ca","tag-infart","tag-menopausia-ca","tag-micronitzada","tag-osteoporosis-ca","tag-progesterona-ca","tag-risc-cardiovascular","tag-terapia-hormonal-ca","tag-trh-ca","tag-trombosis-venosa-ca"],"acf":[],"yoast_head":"\nLa FDA reconsidera els seus advertiments sobre la Ter\u00e0pia Hormonal a la Menopausa: l'inici d'una nova era per a la salut femenina? 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