{"id":3189,"date":"2019-10-25T00:00:00","date_gmt":"2019-10-24T22:00:00","guid":{"rendered":"https:\/\/www.neolifesalud.com\/progesterone-the-lesser-known-hormone-in-hrt\/"},"modified":"2023-01-06T16:50:04","modified_gmt":"2023-01-06T15:50:04","slug":"progesterone-the-lesser-known-hormone-in-hrt","status":"publish","type":"post","link":"https:\/\/www.neolifesalud.com\/en\/blog\/hormonal-balance\/progesterone-the-lesser-known-hormone-in-hrt\/","title":{"rendered":"Progesterone, the lesser known hormone in HRT"},"content":{"rendered":"
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Progesterone is produced in the corpus luteum of the ovaries, a temporary gland that is developed once the egg is released from the ovary after it has matured. The Replenish study showed an improvement in the quality of life of patients who received this therapy.<\/strong><\/h1>\n

Studies show that progesterone is able to reduce hot flashes associated with menopause even in the absence of treatment with estradiol. It is converted into allopregnanolone in the brain, which produces effects on the GABAergic system and induces sleep. Also, when used in conjunction with estradiol, it improves bone mineral density (BMD), among many other benefits.<\/p>\n

Dr. Alfonso Gal\u00e1n Gonz\u00e1lez – Neolife Medical Team<\/em><\/p>\n

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Is it merely the inevitable companion of estradiol in Hormonal Replacement Therapy for menopause?<\/strong><\/p>\n

Progesterone<\/strong> is produced in the corpus luteum of the ovaries<\/strong>. It\u2019s a temporary gland that is developed once the egg is released from the ovary after it has matured.<\/p>\n

\"progesterone\"<\/p>\n

The adrenal glands<\/strong> and the uterus may also produce some progesterone<\/strong>. Progesterone helps prepare the body for pregnancy and causes the endometrium to thicken to receive the fertilized egg. If fertilization does not occur, the corpus luteum<\/strong> is destroyed causing a sharp decrease in this hormone<\/strong>, which in turn causes the endometrium to detach, leading to the onset of menstruation. If the egg is fertilized, the corpus luteum is not destroyed and continues to produce progesterone which, among other things, increases the blood supply to the endometrium, which allows nutrients to reach the embryo that is being formed. When the placenta forms, it also produces progesterone. Levels remain high throughout pregnancy.<\/p>\n

Use in HRT (Hormone Replacement Therapy)<\/strong><\/p>\n

The known use of progesterone in this type of treatment is to prevent the proliferation of the endometrium and endometrial cancer<\/strong> when we use estradiol<\/strong> to replenish hormonal levels during menopause<\/strong> and to reverse the harmful effects that accompany the climateric, which are widely known (1).<\/p>\n

At this point, we\u2019ll consider a number of things related to the additional effects of providing bioidentical progesterone<\/strong> in HRT<\/strong> and the advantages it has over treatments with progestins (synthetic derivatives of non-bioidentical progesterone).<\/p>\n