{"id":3200,"date":"2020-01-24T00:00:00","date_gmt":"2020-01-23T23:00:00","guid":{"rendered":"https:\/\/www.neolifesalud.com\/polyphenols-and-longevity-a-close-relationship\/"},"modified":"2020-01-24T00:00:00","modified_gmt":"2020-01-23T23:00:00","slug":"polyphenols-and-longevity-a-close-relationship","status":"publish","type":"post","link":"https:\/\/www.neolifesalud.com\/en\/blog\/prevention-and-anti-aging\/polyphenols-and-longevity-a-close-relationship\/","title":{"rendered":"Polyphenols and Longevity: A Close Relationship"},"content":{"rendered":"
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Aging involves different cellular mechanisms and metabolic pathways. Each element can be optimized or modulated: caloric intake, exposure to toxic chemicals\/stress, sleep, genetics\/epigenetics, physical activity, and nutrients provided by food. <\/strong><\/h1>\n

Polyphenols are elements in our diet that are present in plants. They have more than one phenol group per molecule. They are divided into groups that include phenolic acids, flavonoids, stilbenes, pterostilbenes, lignans, and tannins. Science is proving that some of these are relevant in the regulation of cellular senescence, in aging and in longevity.<\/p>\n

Dr. Celia Gonzalo Gleyzes – Neolife Medical Team<\/em><\/p>\n

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To clarify a few concepts:<\/strong><\/p>\n

Sirtuins<\/strong> are a family of NAD-dependent protein deacetylase that play a critical role in a large number of biological processes, like the regulation of the cell\u2019s energy state, cellular differentiation, and aging<\/strong>. Sirtuin 1 (Sirt 1), was initially identified in yeast as an important protein in aging. Sirtuin 6 plays a more relevant role in more complex organisms, like humans.<\/p>\n

The link between Sirtuin 6 and Alzheimer’s disease<\/strong> is currently being investigated.<\/p>\n

It is thought to play a part in telomere<\/strong> maintenance, DNA repair, genome integrity, energy metabolism, and inflammation. There\u2019s a deficit of Sirtuin 6 in patients with Alzheimer’s disease, which makes it a future therapeutic target (1) (2).<\/p>\n

Hormesis<\/strong> is a term used by toxicologists to refer to a biphasic dose response to an environmental agent that is characterized by a beneficial stimulation\/effect with low doses and an inhibitory\/toxic effect with high doses<\/a>.<\/p>\n

This is seen as an adaptive response of the cells<\/strong> and the organisms to a moderate (usually intermittent) level of stress<\/strong>. Examples include ischemic preconditioning<\/a>, exercise, caloric restriction, and exposure to low doses of specific phytochemicals<\/a>.<\/p>\n

Hormetic responses involve enzymes like kinases and deacetylases, and transcription factors like Nrf-2 and NF-B. As a result, the cells increase their production of cytoprotective and restorative proteins including growth factors, antioxidant enzymes<\/strong>, and chaperones.<\/p>\n

The famous saying “What doesn’t kill you makes you stronger” rings true in this case, as intermittent or pulsed exposure may produce opposite effects when compared to continuous exposure. Initial exposure may lead to an adaptive stress response with long-lasting protection against subsequent exposures. Stress in early life may increase resilience in later life, and a lack of stress may lead to vulnerability (3) (4).<\/p>\n

Senescence<\/strong> refers to a stable cessation of cell division in cells subjected to a wide variety of types of stress<\/strong>. Cellular senescence plays an important role in various physiological and pathological situations, like development, regeneration, aging<\/strong>, or cancer<\/strong>.<\/p>\n

The elimination of senescent cells with abnormal functioning (with the help of senolytics) would lead to an improvement in the state of the adjacent healthy cells, even perhaps allowing the regeneration of certain tissues.<\/p>\n

\"foods<\/p>\n

Polyphenols with modulating effect on senescence, aging, and longevity<\/strong><\/p>\n