{"id":3225,"date":"2020-07-28T00:00:00","date_gmt":"2020-07-27T22:00:00","guid":{"rendered":"https:\/\/www.neolifesalud.com\/mtor-and-ampk-the-two-sides-of-metabolism-that-you-need-to-be-familiar-with-and-balance-part-ii\/"},"modified":"2023-01-06T16:52:34","modified_gmt":"2023-01-06T15:52:34","slug":"mtor-and-ampk-the-two-sides-of-metabolism-that-you-need-to-be-familiar-with-and-balance-part-ii","status":"publish","type":"post","link":"https:\/\/www.neolifesalud.com\/en\/blog\/prevention-and-anti-aging\/mtor-and-ampk-the-two-sides-of-metabolism-that-you-need-to-be-familiar-with-and-balance-part-ii\/","title":{"rendered":"mTOR and AMPk \u2013 the two sides of metabolism that you need to be familiar with and balance. Part II"},"content":{"rendered":"
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The negative effects of excess activation of the mTOR pathway can lead to cancer, insulin resistance, diabetes, Alzheimer’s, etc. Meanwhile, if we always keep it inhibited, we would affect the creation of tissue, muscle, bone, and cell repair \u2013 leading to sarcopenia, osteoporosis, weakness… and these are the problems of an over-activation of the AMPk pathway.<\/strong><\/h1>\n

In this second part of the articles dedicated to the AMPk and mTOR metabolic pathways, we will try to give some ideas on how to balance these two pathways to get the best out of each of them. At Neolife, we know how to help you with these strategies adapted to your situation and your state of health so that you have an optimal quality of life and state of health.<\/p>\n

Dr. Alfonso Gal\u00e1n Gonz\u00e1lez – Neolife Medical Team<\/em><\/p>\n

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High-intensity exercise, or exercise at high-intensity intervals, such as HIIT, has been shown to activate the AMPk pathway, while strength (weight) training activates the mTOR pathway.<\/strong><\/p>\n

In this second part of the articles dedicated to the AMPk <\/strong> and mTOR<\/strong> metabolic pathways, we will try to give some ideas on how to balance these two pathways to get the best out of each one.<\/p>\n

Scientific interest in them has been increasing in recent years, as shown by the number of articles published in Pubmed when you search for mTOR:<\/p>\n

\"mTOR\"<\/p>\n

And for AMPk:<\/p>\n

\"AMPK\"<\/p>\n

We mentioned in the previous article that the negative effects of excess activation of the mTOR pathway<\/strong> can lead to cancer, insulin resistance, diabetes, Alzheimer’s, Parkinson\u2019s, etc<\/strong>. Meanwhile, if we always keep it inhibited, we would affect the creation of tissue, muscle, bone, and cell repair \u2013 leading to sarcopenia, osteoporosis, weakness<\/strong>… and these are the problems of an over-activation of the AMPk<\/strong> pathway \u2013 mTOR\u2019s \u201cantagonistic\u201d pathway.<\/p>\n

Thus, we do not want to develop diabetes, neurodegenerative and cardiovascular diseases, or cancer; however, we also do not want to lose bone mass<\/strong> or muscle mass<\/strong>, which we need in order to have an adequate metabolic rate to promote the burning of fat and glucose.<\/p>\n

Life in industrialized society almost inevitably leads us to an excess of mTOR<\/strong> activation, as we have plenty of food, we can eat as many times a day as we want (always maintaining high sugar levels with the consequent release of insulin), and we have sedentary jobs not needing to undertake physical activity to get our food. As we have seen, these are the things that inhibit AMPk pathway activation<\/strong> and that may be the cause of the increase in metabolic diseases<\/strong> in recent decades. Obviously, if we think about how the first humans lived, we can see that inevitably there was an alternation between exercise and rest, between eating and fasting…<\/p>\n

Currently, we could say that we have to “simulate” all of that in order to improve our state of health<\/strong> and get the benefits of both metabolic pathways while avoiding the negative effects at the same time.<\/p>\n

I hope I have been able to convey that neither of the pathways is good or bad; it is a balance between the two that will lead us to greater longevity, a life free of disease, to avoid the loss of muscle mass and bone mass, etc.<\/p>\n

How do we balance both pathways?<\/strong><\/p>\n

Alluding to the 4 fundamental pillars of treatment of Age Management Medicine<\/strong> and of Neolife<\/strong> (which we can expand to many more, but for educational and practical purposes we will reduce to 4) which are nutrition, exercise, supplementation, and hormonal balance<\/strong>, we will briefly explain what can be done.<\/p>\n