{"id":3259,"date":"2021-03-26T00:00:00","date_gmt":"2021-03-25T23:00:00","guid":{"rendered":"https:\/\/www.neolifesalud.com\/covid-nad-and-our-immune-system\/"},"modified":"2021-03-26T00:00:00","modified_gmt":"2021-03-25T23:00:00","slug":"covid-nad-and-our-immune-system","status":"publish","type":"post","link":"https:\/\/www.neolifesalud.com\/en\/blog\/prevention-and-anti-aging\/covid-nad-and-our-immune-system\/","title":{"rendered":"COVID, NAD, and Our Immune System"},"content":{"rendered":"
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An important way to activate our cellular immunity is by activating PARPs. These consume NAD, and when there is none or very little left, they can no longer be activated. They don\u2019t activate our cellular immunity and the virus is free to continue replicating and damaging us.<\/strong><\/h1>\n

NAD intervenes vitally in two very important pathways in humans, namely the sirtuin and PARP pathways. It is essential in functions that influence the aging process, such as mitochondria synthesis, apoptosis, autophagy, inflammation, intracellular and systemic signaling, DNA repair, genomic stability, programmed cell death… and our immunity.<\/p>\n

Dr. Alfonso Gal\u00e1n Gonz\u00e1lez – Neolife Medical Team<\/em><\/p>\n

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T<\/strong>he activation of NAMPT and providing NAM and NR dramatically lower the replication capacity of a coronavirus model that is sensitive to PARP activity.<\/strong><\/p>\n

Scientific knowledge has given us an incredible surprise very recently. Keep reading, and you’ll understand everything perfectly.<\/p>\n

A few weeks ago, we posted in this blog an article on the importance of NAD<\/strong> in cellular metabolism, the aging<\/strong> process, gene expression, DNA<\/strong> repair, and other fundamental functions, and we showed you what we can do to improve its levels so that our body may function in the most optimal way. You may read this article here.<\/a> I recommend it so you may better understand the results of the research that we will present below.<\/p>\n

We said that there are two vital pathways in the human body in which the presence of NAD<\/strong> is essential: the sirtuin<\/strong> and PARP<\/strong> pathways.<\/p>\n

Sirtuins<\/strong> are a group of enzymes that regulate functions that influence the aging<\/strong> process, such as mitochondria synthesis, apoptosis, autophagy, inflammation, intracellular and systemic signaling, DNA repair, etc. And PARP<\/strong> or poly (ADP-ribose) polymerase is a family of proteins involved in DNA repair, genomic stability, and programmed cell death.<\/p>\n

We presented this chart of NAD<\/strong> synthesis to explain how our body is able to synthesize it and what we can do to improve this synthesis by providing various supplements or enhancing the activity of various enzymes with different strategies.<\/p>\n

\"NAD<\/p>\n

Well, this latest study by Dr. Charles Brenner’s team at the City Of Hope National Medical Center in California (USA)<\/em> shows us that, within the PARP<\/strong> group, these enzymes that are primarily associated with DNA<\/strong> repair and that depend on NAD<\/strong> and therefore consume our reserves of it, there is a subgroup known as MARylating<\/strong> (mono-ADP-ribosylating) PARPs that are associated with antiviral cellular response. This study shows that:<\/p>\n