How to improve joint function?


The new supplement by Neoactives, NeoJoint formula, is a calculated mixture of the most relevant natural compounds for supplementation to protect joint cartilage damaged during day to day life and by performing physical activity improperly.

This formula contains all the elements that the human body’s connective tissue (bone, cartilage, hair, skin…) needs to function properly. Its supplementation may help slow normal progressive age-related degeneration in patients with evident clinical manifestations, such as chronic osteoarthritis.

Dr. Francisco Martínez Peñalver – Neolife Medical Team


The combination of glucosamine sulfate and chondroitin sulfate supplements has shown to be very effective for the control of inflammatory joint diseases.

The new supplement by Neoactives, NeoJoint formula, is a calculated mixture of the most relevant natural compounds for supplementation to protect joint cartilage damaged during day to day life and by performing physical activity improperly. It contains glucosamine, chondroitin, MSM, hyaluronic acid, type II collagen, silicon and vitamin C.

Glucosamine sulfate is a natural product found in the human body among other places in nature. It is responsible for stabilizing the situation in places where cartilaginous tissue is damaged or degraded by the synthesis of proteoglycans at that level. In the case of acute joint processes, there have been comparative studies with NSAIDs (non-steroidal anti-inflammatory drugs) to treat acute arthritis dating back over 20 years, where it has been observed that, at the very least, supplementation with glucosamine achieves the same effects in cases of arthritis and don’t present the same gastrointestinal and cardiovascular side effects NSAIDs (1). In long-term treatments, when slowing down the progression of arthrosis or joint degeneration after multiple episodes of arthritis, glucosamine has been revealed as an effective and very safe treatment for delaying the progression of injuries and improving symptoms of joint pain and swelling (2 and 3).

joints

Chondroitin sulfate is a molecule belonging to the glycosaminoglycans family, which is responsible for the aggregation of proteoglycans that will be fundamental in the production of collagen fibrils. It is an essential structural element in connective tissues (cartilage, skin, blood vessel walls, and, of course, ligaments and tendons). According to the European Traumatology Society, there is 1-A evidence (the highest degree of scientific evidence) for its use in osteoarthritis of the knee (4). Studies that demonstrate their efficacy in slowing the progression of the disease and in avoiding joint space narrowing (typical symptom of chronic osteoarthritis) also make it very clear that it has a safety profile with no serious side effects. We’re talking, therefore, about an effective and safe supplement (5). When comparing its action to that of NSAIDs, ignoring obvious differences due to poor gastrointestinal tolerance of the latter, symptoms relief begins slower with chondroitin sulfate but is maintained over a period of 3-6 months after completing treatment, while in the case of NSAIDs, joint symptoms, especially pain, return within a few days of ending treatment (6).

Another component of Neoactive’s joint formula is methylsulfonylmethane, best known by its acronym MSM. The MSM is an organic sulfur compound, sulfur being the third component of our body. Normally, a balanced diet should contain a sufficient amount of sulfur, but that generally does not occur in the population. Supplementation with MSM, apart from having demonstrated total safety in terms of the absence of side effects, produces rapid improvements in joint mobility and disappearance of symptoms such as pain (7), which likewise facilitates the patient’s ability to perform basic activities of daily life.

Type II collagen is collagen in its original triple helix shape. It helps reduce pain and joint inflammation, boosts joint functionality (in terms of flexibility and mobility), compensates physiological destruction of type II collagen that occurs on a daily basis in our body, and therefore it helps stop the processes of joint wear and erosion, which are considered natural and caused by aging.  In comparative studies with other molecules, such as glucosamine, type II collagen has been shown to be both a much more efficient molecule and a very safe molecule with no side effects (8).

Silicon is the second most abundant element on earth after carbon. It is a fundamental component of the extracellular matrix that serves as the basis for the formation of connective tissue in general, but especially of bone and cartilage. It is considered one of the most important elements in terms of improving the elasticity and hardness of the skin because it is an essential element for the correct synthesis of collagen. It also helps delay hair loss and boosts shine (9).

The last of the elements that make up this joint formula is vitamin C. It has been used for more than 30 years as an “accelerator” for scarring in post-surgical wounds and as a complementary treatment in acute reactivations of chronic diseases such as COPD (10).

This formula contains all the elements that the human body’s connective tissue (bone, cartilage, hair, skin…) needs to function properly. Its supplementation may help slow normal progressive age-related degeneration in patients with evident clinical manifestations, such as chronic osteoarthritis.


BIBLIOGRAPHY

(1) Qiu Gx et al. Efficacy and safety of glucosamine sulfate versus ibuprofen in patients with knee osteoarthritis. Arzneimittelforschung. 1998 May;48(5):469-74.

(2) Poolsup N et al. Glucosamine long-term treatment and the progression of knee osteoarthritis: systematic review of randomized controlled trials. Ann Pharmacother. 2005 Jun;39(6):1080-7.

(3) Reginster JY et al. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo controlled clinical trial. Lancet . 2001Jan 27;357(9252):251-6.

(4) Uebelhart D et al. Clinical review of chondroitin sulfate in osteoarthritis. Osteoarthritis Cartilage. 2008;16 Suppl 3: S19-21.

(5) Uebelhart D et al. Effects of oral chondroitin sulphate on the progression of knee osteoarthritis: a pilot study. Osteoarthritis Cartilage. 1998 May;6 Suppl A: 39-46.

(6) Morreale P et al. Comparison of the anti-inflammatory efficacy of chondroitin sulfate and diclofenac sodium in patients with knee osteoarthritis. J Rheumatol. 1996 Aug;23(8):1385-1391.

(7) Alekseeva Ll et al. Use of Artra MSM Forte in patients with knee osteoarthritis: Results of a randomized open-label comparative study of the efficacy and tolerability of the drug. Ter Arkh. 2015;87(12):49-54.

(8) Lugo JP et al. Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo controlled study. Nutr J. 2016 Jan 29;15:14

(9) Araujo LA et al. Use of silicon for skin and hair care: an approach of chemical forms available and efficacy. An Bras Dermatol. 2016 May-Jun;91(3):331-5.

(10) Moores J et al. Vitamin C: a wound healing perspective. Br J Community Nurs. 2013 Dec;Suppl:S6, S8-11.


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